Synthesisof a peptide that can translocate to the endoplasmic reticulum.
Nakatsu K,Hosoi T, Toyoda K,Ozawa K.
BiochemBiophys Res Commun. 2015 May 8;460(3):628-32. doi: 10.1016/j.bbrc.2015.03.080.Epub 2015 Mar 21.
Possibleinvolvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development ofleptinresistance.
Hosoi T,Matsuzaki S, Miyahara T, Shimizu K, Hasegawa Y,Ozawa K.
J Neurochem.2015 May;133(3):343-51. doi: 10.1111/jnc.13057. Epub 2015 Mar 2.
Leptininduced GRP78 expression through the PI3K-mTOR pathway in neuronal cells.
Thon M, HosoiT, Yoshii M,Ozawa K.
Sci Rep. 2014Nov 18;4:7096. doi: 10.1038/srep07096.
Therapeuticpotential of flurbiprofen against obesity in mice.
Hosoi T, BabaS,Ozawa K.
BiochemBiophys Res Commun. 2014 Jun 20;449(1):132-4. doi: 10.1016/j.bbrc.2014.04.159.Epub 2014 May 9.
TERTattenuated ER stress-induced cell death.
Hosoi T, InoueY, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, Tahara H,Ozawa K.
BiochemBiophys Res Commun. 2014 May 2;447(2):378-82. doi: 10.1016/j.bbrc.2014.04.034.Epub 2014 Apr 16.
Caffeineattenuated ER stress-induced leptin resistance in neurons.
Hosoi T,Toyoda K, Nakatsu K,Ozawa K.
Neurosci Lett.2014 May 21;569:23-6. doi: 10.1016/j.neulet.2014.03.053. Epub 2014 Mar 31.
Inhibitionof inducible nitric oxide synthase and interleukin-1β expression bytunicamycinin cultured glial cells exposed to lipopolysaccharide.
Hosoi T,Noguchi J, Takakuwa M, Honda M, Okuma Y, Nomura Y,Ozawa K.
Brain Res.2014 Apr 16;1558:11-7. doi: 10.1016/j.brainres.2014.02.035. Epub 2014 Feb 24.
Flurbiprofenameliorated obesity by attenuating leptin resistance induced byendoplasmicreticulum stress.
Hosoi T,Yamaguchi R, Noji K, Matsuo S, Baba S, Toyoda K, Suezawa T, Kayano T, Tanaka S,Ozawa K.
EMBO Mol Med.2014 Mar;6(3):335-46. doi: 10.1002/emmm.201303227. Epub 2014 Jan 13.
ERstress upregulated PGE?/IFNγ-induced IL-6 expression and down-regulatediNOSexpression in glial cells.
Hosoi T, HondaM, Oba T,Ozawa K.
Sci Rep. 2013Dec 2;3:3388. doi: 10.1038/srep03388.
ERstress-mediated regulation of immune function under glucose-deprived conditionin glialcells: up- and down-regulation of PGE2 + IFNγ-induced IL-6 and iNOSexpressions.
Hosoi T, ObaT,Ozawa K.
BiochemBiophys Res Commun. 2013 Nov 15;441(2):525-8. doi: 10.1016/j.bbrc.2013.10.109.Epub 2013 Oct 29.
TNF-α-857C>T genotype is predictive of clinical response after treatmentwithdefinitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanesepatients withesophageal squamous cell carcinoma.
Omatsu H,Kuwahara A, Yamamori M, Fujita M, Okuno T, Miki I, Tamura T, Nishiguchi K,Okamura N, Nakamura T, Azuma T, Hirano T,Ozawa K, Hirai M.
Int J Med Sci.2013 Oct 15;10(12):1755-60. doi: 10.7150/ijms.6749. eCollection 2013.
Tributyltin-inducedendoplasmic reticulum stress and its Ca(2+)-mediated mechanism.
Isomura M,Kotake Y, Masuda K, Miyara M, Okuda K, Samizo S, Sanoh S, Hosoi T,Ozawa K,Ohta S.
Toxicol ApplPharmacol. 2013 Oct 1;272(1):137-46. doi: 10.1016/j.taap.2013.05.026. Epub 2013Jun 3.
Serotonergicmodulation of neuronal activity in the nucleus accumbens followingrepeatedmethamphetamine administration in rats.
Ishihara K,Takahashi N, Komoto N, Yoshikawa C, Fukumoto S, Ide S, Kimura T,Ozawa K.
J PharmacolSci. 2013;123(2):140-6. Epub 2013 Oct 4.
Inhibitionof casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responsesincultured glial cells.
Hosoi T,Korematsu K, Horie N, Suezawa T, Okuma Y, Nomura Y,Ozawa K.
PLoS One.2012;7(6):e40144. doi: 10.1371/journal.pone.0040144. Epub 2012 Jun 29.
Fluvoxamineattenuated endoplasmic reticulum stress-induced leptin resistance.
Hosoi T,Miyahara T, Kayano T, Yokoyama S,Ozawa K.
FrontEndocrinol (Lausanne). 2012 Jan 30;3:12. doi: 10.3389/fendo.2012.00012.eCollection 2012.
[Developmentof advanced pharmacy practice experience in national universities].
Ozawa K, Sugawara M, Sekine Y, Nakashima M.
YakugakuZasshi. 2012;132(3):345-50. Review. Japanese.
Molecularapproaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease:endoplasmic reticulum stress and immunological stress in pathogenesis ofAlzheimer'sdisease.
Hosoi T,OzawaK.
J PharmacolSci. 2012;118(3):319-24. Epub 2012 Mar 2. Review.
Stearoyl-CoADesaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficientmice.
Yokoyama S,Hosoi T,Ozawa K.
Gene. 2012 Apr15;497(2):340-3. doi: 10.1016/j.gene.2012.01.024. Epub 2012 Feb 3.
TEK/Tie2is a novel gene involved in endoplasmic reticulum stress.
Hosoi T,Tamubo T, Horie N, Okuma Y, Nomura Y,Ozawa K.
J PharmacolSci. 2010;114(2):230-3.
Myeloiddifferentiation factor 88 (MyD88)-deficiency increases risk of diabetes inmice.
Hosoi T,Yokoyama S, Matsuo S, Akira S,Ozawa K.
PLoS One. 2010Sep 2;5(9). pii: e12537. doi: 10.1371/journal.pone.0012537.
Homocysteineinduces X-box-binding protein 1 splicing in the mice brain.
Hosoi T, OgawaK,Ozawa K.
Neurochem Int.2010 Jan;56(2):216-20. doi: 10.1016/j.neuint.2009.12.005. Epub 2009 Dec 16.
Aunique modulator of endoplasmic reticulum stress-signalling pathways: thenovelpharmacological properties of amiloride in glial cells.
Hosoi T, KumeA, Otani K, Oba T,Ozawa K.
Br J Pharmacol.2010 Jan 1;159(2):428-37. doi: 10.1111/j.1476-5381.2009.00544.x. Epub 2009 Dec15.
MyD88plays a key role in LPS-induced Stat3 activation in the hypothalamus.
Yamawaki Y,Kimura H, Hosoi T,Ozawa K.
Am J PhysiolRegul Integr Comp Physiol. 2010 Feb;298(2):R403-10. doi:10.1152/ajpregu.00395.2009. Epub 2009 Dec 2.
Endoplasmicreticulum stress in disease: mechanisms and therapeutic opportunities.
Hosoi T,OzawaK.
Clin Sci(Lond). 2009 Sep 28;118(1):19-29. doi: 10.1042/CS20080680. Review.
Developmentof clinical application for a nutritional prescription support system fortotalparenteral/enteral nutrition.
Masuda S, OkaR, Uwai K, Matsuda Y, Shiraishi T, Nakagawa Y, Shoji T, Mihara C, Takeshita M,OzawaK.
YakugakuZasshi. 2009 Sep;129(9):1077-86.
Possibleinvolvement of endoplasmic reticulum stress in obesity associated withleptinresistance.
Hosoi T,OzawaK.
J Med Invest.2009;56 Suppl:296-8. Review.
Effectof pranoprofen on endoplasmic reticulum stress in the primary cultured glialcells.
Hosoi T,Sasaki M, Baba S,Ozawa K.
Neurochem Int.2009 Jan;54(1):1-6. doi: 10.1016/j.neuint.2008.09.017. Epub 2008 Dec 9.
Endoplasmicreticulum stress induces leptin resistance.
Hosoi T,Sasaki M, Miyahara T, Hashimoto C, Matsuo S, Yoshii M,Ozawa K.
Mol Pharmacol.2008 Dec;74(6):1610-9. doi: 10.1124/mol.108.050070. Epub 2008 Aug 28.
Vanadateinhibits endoplasmic reticulum stress responses.
Hosoi T, SaitoA, Kume A, Okuma Y, Nomura Y,Ozawa K.
Eur JPharmacol. 2008 Oct 10;594(1-3):44-8. doi: 10.1016/j.ejphar.2008.07.034. Epub 2008Jul 30.
Theactivation of apoptosis factor in hindlimb unloading-induced muscle atrophyunder normaland low-temperature environmental conditions.
Nagano K,Suzaki E, Nagano Y, Kataoka K,Ozawa K.
Acta Histochem.2008;110(6):505-18. doi: 10.1016/j.acthis.2007.12.009. Epub 2008 Apr 16.
[Comparativestudy of drug efficacy and drug additives between generic drugs andoriginaldrugs].
Katoh H, YoshiiM,Ozawa K.
YakugakuZasshi. 2007 Dec;127(12):2035-44. Japanese.
Nanokineticsof drug molecule transport into a single cell.
Tamura A,OzawaK, Ohya T, Tsuyama N, Eyring EM, Masujima T.
Nanomedicine(Lond). 2006 Oct;1(3):345-50.
Aktup- and down-regulation in response to endoplasmic reticulum stress.
Hosoi T, HyodaK, Okuma Y, Nomura Y,Ozawa K.
Brain Res.2007 Jun 4;1152:27-31. Epub 2007 Mar 24.
UCN-01(7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primaryandmetastatic oral cancer cell lines in vitro.
Otsubo A,Bhawal UK, Nomura Y, Mitani Y,Ozawa K, Kuniyasu H, Sugiyama M.
Oral Surg OralMed Oral Pathol Oral Radiol Endod. 2007 Mar;103(3):391-7. Epub 2006 Jul 11.
Inhibitoryeffect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine proteaseinhibitor, onPI3K inhibitor-induced CHOP expression.
Hosoi T, HyodaK, Okuma Y, Nomura Y,Ozawa K.
Eur JPharmacol. 2007 Jan 5;554(1):8-11. Epub 2006 Oct 10.
Aconvenient method for the evaluation of anti-tumor agents affecting the cellcycle.
Ikeda K, PantB, Mishiro A,Ozawa K, Masujima T, Sugiyama M.
J BiosciBioeng. 2000;90(5):574-6.
Augmentationof serotonin-induced inhibition of neuronal activity in the hippocampusfollowingrepeated treatment with methamphetamine.
Kimura T,Ishihara K,Ozawa K, Sasa M.
Ann N Y AcadSci. 2004 Oct;1025:242-7.
[Activeinvolvement of pharmacists in initial treatments for acute poisoning andoverdosedpatients in the intensive care unit].
Ihara K, UneiH, Iwasaki Y, Yashiki M, Tanigawa K, Kihira K,Ozawa K.
Chudoku Kenkyu.2003 Oct;16(4):433-40. Japanese.
Disuseatrophy alterations in normal and low temperature environments duringhindlimbunloading in Syrian hamsters.
Nagano K,Kajihara H, Suzaki E, Suzuto M, Kataoka K, Yoshii M,Ozawa K.
Cryo Letters.2003 Jul-Aug;24(4):245-52.
Video-microscopyfor analysis of molecular dynamics in cells.
Ozawa K, Tamura A, Ikeda K, Kawai E, Kondo T, FukanoY, Nomura S, Ishihara Y, Masujima T.
J Pharm BiomedAnal. 1997 Jun;15(9-10):1483-8.
Trappingof secreted molecules at single-cell level using an HPLC resin particle underavideomicroscope.
Masujima T,Ikeda K,Ozawa K, Tamura A, Tada Y, Ohya H, Suzuto M.
Biol PharmBull. 1998 Aug;21(8):886-8.
Determinationof insulin content in pancreatic beta cell line MIN6 cells by matrix-assistedlaser desorption ionization time-of-flight mass spectrometry.
Tamura A,Azuma T, Ikeda K,Ozawa K, Masujima T.
Biol PharmBull. 1998 Nov;21(11):1240-1.
Quantitativeanalysis of exocytosis visualized by a video-enhanced light/fluorescencemicroscope reveals two distinct components of exocytosis in RBL-2H3 cells.
Ozawa K, Kobayashi H, Kawai E, Suzaki E, Nonomura Y,Masujima T.
FEBS Lett.1996 Nov 25;398(1):67-73.
Differentpathways of inhibitory effects of wortmannin on exocytosis are revealed byvideo-enhanced light microscope.
Ozawa K, Masujima T, Ikeda K, Kodama Y, Nonomura Y.
BiochemBiophys Res Commun. 1996 May 15;222(2):243-8.
Antiallergicdimeric prenylbenzoquinones from Ehretia microphylla.
Yamamura S,Simpol LR,Ozawa K, Ohtani K, Otsuka H, Kasai R, Yamasaki K, PadolinaWG.
Phytochemistry.1995 May;39(1):105-10.
HistamineH2-receptor in atrium: signal transduction and response.
Ozawa K, Fujishima Y, Segawa T.
Agents ActionsSuppl. 1991;33:295-300.
Histamineincreases phospholipid methylation and H2-receptor-adenylate cyclase couplinginrat brain.
Ozawa K, Segawa T.
J Neurochem.1988 May;50(5):1551-8.
Phospholipidmethylation participates in H2-receptor mediated stimulation ofadenylatecyclase in rat brain.
Segawa T,OzawaK.
Adv Exp MedBiol. 1988;236:329-41. No abstract available.
Mechanismof Cu(2+)-induced elevation of [(3)H]cimetidine binding to membranes in ratbrain.
Ozawa K, Nomura Y, Segawa T.
Neurochem Int.1985;7(3):435-40.
